VivoNu Cayenne Pepper equivalent to 1000 mg of fresh cayenne per softgel is a 12-in-1 Advanced Botanical Formula that pairs cayenne with Vitamin D3, Vitamin K2, Vitamin E and Grape Seed Oil, plus a blend of curcumin, black pepper, hawthorn, cinnamon, berberine, beetroot and ginseng, in a bag of 240 softgels. It is designed for people with constantly cold hands and feet, heaviness and sluggishness after meals, low daily energy and weak digestion, and for anyone who wants to support circulation and vascular health at the root. These complaints often share the same underlying drivers: unstable blood sugar and high insulin wearing down the lining of the blood vessels, low-grade chronic inflammation, oxidative damage to fats and artery walls, low vitamin D and vitamin E status, and sluggish digestive secretions. That is why this formula works on several fronts at once: cayenne to stimulate circulation and digestion, cinnamon and berberine to support healthy blood sugar, curcumin with black pepper to calm inflammation, beetroot and hawthorn to support flexible vessels and the heart, and ginseng for energy and stress resilience, all delivered with fat-soluble vitamins in an oil base that helps them absorb.
What Is Cayenne Pepper 12-in-1?
Cayenne pepper (Capsicum annuum) is a hot red chili, and its best-known active compound is capsaicin, the molecule behind the heat. In this formula, cayenne comes as Cayenne Pepper Seed Oil from the fruit, at 300 mg per 3 softgels, extracted from 3000 mg of fresh cayenne, which works out to the equivalent of about 1000 mg of fresh pepper per softgel. Alongside it are Grape Seed Oil, rich in unsaturated fats; Vitamin D3 (cholecalciferol), the same form your skin makes in sunlight; Vitamin K2; and Vitamin E as alpha-tocopherol equivalents. The formula is completed by a Proprietary Blend of seven botanicals: Curcumin (98%) from turmeric, Black Pepper Extract, Hawthorn Extract, Cinnamon Extract, Berberine Extract, Beet Root Extract and Ginseng Extract. Together, that makes twelve ingredients.
Benefits of Cayenne Pepper 12-in-1
- Supports circulation: Capsaicin helps small blood vessels widen and increases blood flow to the extremities, which many people feel as warmth in cold hands and feet.
- Supports digestion: Cayenne stimulates saliva and digestive juices, helping ease heaviness, bloating and slow digestion after meals.
- Supports healthy blood sugar: Cinnamon and berberine are among the best-known botanicals for supporting insulin sensitivity, helping reduce post-meal energy crashes and sugar cravings.
- Calms inflammation: Curcumin is one of the most powerful anti-inflammatory plant compounds, and black pepper alongside it markedly improves its absorption.
- Heart and vascular support: Hawthorn is a traditional heart herb, and beetroot provides nitrates the body converts into nitric oxide, which relaxes blood vessel walls.
- Antioxidant protection: Vitamin E protects cell membranes and blood fats from oxidation, a key step in protecting the artery lining.
- Immune, bone and mood support: Vitamin D3 provides 125% of the Daily Value per 3 softgels, essential for calcium absorption, immune function and overall vitality.
- Energy and stress resilience: Ginseng is an adaptogen that helps the body cope with stress, supporting energy and focus without a harsh stimulant effect.
How Cayenne Pepper 12-in-1 Works in the Body
Capsaicin binds to receptors on sensory nerves called TRPV1, the same receptors that sense heat. When they are activated, the body responds by opening up tiny blood vessels and increasing blood flow, slightly raising heat production, and stimulating stomach and intestinal secretions. That is why cayenne has long been linked with warmth, active digestion and a sense of vitality.
The root question is why circulation weakens and the body slows down in the first place. In many people, the first driver is insulin resistance. Diets heavy in sugar and refined starches, and eating frequently throughout the day, keep insulin elevated. High insulin combined with excess glucose strains the inner lining of the blood vessels and reduces its ability to make nitric oxide, the molecule that keeps vessels flexible and open. This is where cinnamon and berberine come in: berberine helps activate AMPK, the cell's energy switch that improves glucose uptake, while cinnamon supports the cell's response to insulin. Beetroot completes the picture by supplying nitrates that the body turns into nitric oxide.
The second driver is chronic inflammation and oxidation. When blood fats oxidize and the vessel lining becomes inflamed, slow damage to the arteries begins. Curcumin helps quiet inflammatory pathways inside the cell, Vitamin E shields fats and cell membranes from oxidation, and hawthorn adds flavonoids that support the heart and vessels. Black pepper contains piperine, which slows the breakdown of curcumin in the liver and gut so it stays in the body longer.
The third driver is stress and cortisol. Chronic stress raises cortisol, and cortisol raises blood sugar, constricts blood vessels and drains energy. Ginseng supports the body's ability to adapt to that pressure.
Absorption matters too. Vitamin D3, Vitamin E, curcumin and cayenne oil are all fat-soluble, so they depend on dietary fat and healthy bile flow from the liver and gallbladder. If you get bloated after fatty meals or feel discomfort under the right ribs, bile flow may be sluggish, which limits how well you absorb fat-soluble nutrients. Vitamin D also needs magnesium to convert into its active form, so low magnesium blunts its benefits. Common depleters include excess sugar, smoking (which burns through antioxidants), little sun exposure, excess body fat that traps vitamin D in tissue, and ongoing stress.
What Makes This Formula Stand Out
The main strength of this formula is that it brings together, in one product, ingredients that address connected root causes: circulation, blood sugar, inflammation, oxidation and stress. Instead of a single-ingredient cayenne supplement, you get 100 mg of Cayenne Pepper Seed Oil per softgel, equivalent to about 1000 mg of fresh pepper, plus 100 mg of Grape Seed Oil per 3 softgels. The softgel format with an oil base suits fat-soluble ingredients, is easy to swallow and spares your mouth the direct bite of cayenne.
The daily dose of 3 softgels provides 1000 IU of Vitamin D3 and 15 mg α-TE of Vitamin E, covering 100% of the Daily Value. Vitamin K2 is listed at 150 ng per 3 softgels, less than 1% of the Daily Value, so its presence is token; to get the full benefit of the D3 and K2 partnership in directing calcium toward bones and away from arteries, you will want an additional K2 source from food or a separate supplement. The Proprietary Blend provides 50 mg per 3 softgels shared across seven extracts, including Curcumin (98%) and Berberine, which the label adds to the ingredients named in the title. The formula is free of gluten, dairy, eggs, fish/shellfish, peanuts and tree nuts, has no added sugar, and is described by the brand as non-GMO. Note that the softgels contain gelatin and carmine (a natural red color derived from insects), so they are not suitable for vegetarians or vegans despite the plant-based wording on the front, and they also contain soybean oil.
Who Is This Product For?
- People with cold hands and feet who want to support peripheral circulation.
- Anyone who feels heavy, sluggish or bloated after meals and needs digestive support.
- Those who notice energy crashes and sugar cravings after eating and are working on blood sugar balance.
- People focused on heart and vascular health who want anti-inflammatory and antioxidant support.
- Anyone who spends most of the day indoors and needs a daily source of Vitamin D3.
- People under constant stress and fatigue looking for support with energy and endurance.
How to Use
Per the label, adults take 3 softgels daily, and consulting your physician is recommended for best results. Take them with a meal that includes healthy fats such as eggs, avocado or olive oil, since Vitamin D3, Vitamin E and curcumin absorb better with fat and bile, and food also reduces any stomach warmth from the cayenne. You can take all 3 softgels together with breakfast or lunch, or split them across two meals. Taking them earlier in the day is best if ginseng affects your sleep. To get more from the formula, cut back on sugar and refined starches, make sure your magnesium intake is adequate to activate vitamin D, and add a good source of Vitamin K2. One bag lasts 80 days at the suggested dose.
Product Details
- Cayenne Pepper: 100 mg Cayenne Pepper Seed Oil per softgel, equivalent to about 1000 mg fresh pepper (300 mg per 3 softgels, from 3000 mg fresh cayenne).
- Grape Seed Oil: 100 mg per 3 softgels.
- Vitamin D3: 1000 IU per 3 softgels (125% DV).
- Vitamin K2: 150 ng per 3 softgels as printed on the label (less than 1% DV).
- Vitamin E: 15 mg α-TE per 3 softgels (100% DV).
- Proprietary Blend: 50 mg per 3 softgels, containing Curcumin (98%) (From Turmeric), Black Pepper Extract, Hawthorn Extract, Cinnamon Extract, Berberine Extract, Beet Root Extract and Ginseng Extract.
- Other Ingredients: Soybean Oil, Gelatin, Glycerin, Mono-and Diglycerides Of Fatty Acids, Water, Carmine.
- Free of: Gluten, Dairy, Eggs, Fish/Shellfish, Peanuts and Tree Nuts.
- Daily Dose: 3 softgels.
- Form: Softgels.
- Count: 240 softgels.
- Brand: VivoNu.
- Country of Origin: China.
Frequently Asked Questions
Is the 1000 mg in the title per softgel or per daily dose?
The 1000 mg figure refers to a single softgel, and it is a fresh-pepper equivalent rather than the weight of the oil itself. Each softgel contains 100 mg of Cayenne Pepper Seed Oil derived from about 1000 mg of fresh pepper, and the daily dose of 3 softgels provides 300 mg of oil, equivalent to 3000 mg of fresh pepper.
Does cayenne cause heartburn?
The softgel limits contact between cayenne and your mouth and esophagus, but people with sensitive stomachs may notice mild warmth or burning. Taking the softgels with food reduces this noticeably, and anyone with an active ulcer or reflux should check with their doctor first.
Why is black pepper paired with turmeric in this formula?
Curcumin on its own is poorly absorbed and broken down quickly in the liver and gut. Black pepper contains piperine, which slows that breakdown and increases how much curcumin reaches the bloodstream, and the oil base of the softgel supports absorption further.
Is this product suitable for vegetarians or vegans?
No. Although the front of the pack describes it as plant based, the other ingredients include gelatin in the softgel shell and carmine as a colorant, both of animal origin. The active ingredients themselves are mostly plant derived.
Caution
Consult your doctor if pregnant, nursing or taking long-term medication, especially blood thinners, blood pressure or diabetes medication.
