NaturesPlus Ultra-Zyme Maximum Strength Digestive Enzymes comes in a bottle of 90 tablets, with every two tablets delivering 325 mg of 4x (quadruple strength) Pancreatin alongside Ox Bile, Bromelain, Pepsin, Papain, Lactase and Cellulase, plus stomach acid support, probiotics and a whole food herbal blend. It is made for people who feel heavy and bloated after meals, who feel food sitting in the stomach for hours, who burp a lot or struggle with fatty foods, who notice undigested food or discomfort after dairy, and who eat well yet still feel tired, as if their body is not getting much from their food. These symptoms rarely mean the stomach is simply "sensitive." More often they point to a weak digestive chain from the very start: too little stomach acid, which means the pancreas is not properly signaled to release its enzymes, which means bile does not flow well enough to break down fat. Ultra-Zyme supports that whole chain at once, from the stomach to the small intestine, as part of an approach that also tackles what weakened digestion in the first place, such as stress, sugar and rushed eating.
What Is Ultra-Zyme Digestive Enzymes?
Digestive enzymes are specialized proteins released in the mouth, stomach and pancreas to break food into pieces small enough to absorb: protein into amino acids, fat into fatty acids, and starch into simple sugars. Ultra-Zyme is a broad-spectrum formula that draws on several enzyme sources. At its core is Pancreatin, a natural animal-derived blend of pancreatic enzymes that provides amylase for starches, protease (trypsin and chymotrypsin) for protein, and lipase for fat. It is joined by Pepsin, the stomach's main protein-digesting enzyme; Bromelain from pineapple stem and Papain from papaya latex, two plant enzymes that break down protein; Cellulase, which breaks down plant cell walls; and Lactase, which digests milk sugar. Ox Bile supplies bile salts that emulsify fat and prepare it for lipase to do its job.
Benefits of Ultra-Zyme Digestive Enzymes
- Less heaviness and bloating after meals: When food is digested efficiently, it does not linger in the stomach or ferment in the gut, so that stuffed, gassy feeling after eating tends to ease.
- Better protein digestion: Pepsin, protease, bromelain and papain work together on meat, eggs and legumes, freeing the amino acids your body uses to build muscle, enzymes and neurotransmitters.
- Comfort with richer foods: Ox bile and lipase team up to break down fat, which helps people who feel nauseous or heavy after fatty meals, especially when the gallbladder is sluggish.
- Support for fat-soluble nutrient absorption: Vitamins A, D, E and K and omega-3s need adequate bile to be absorbed, so better fat digestion supports getting them where they need to go.
- Stomach acid support: Betaine HCl and L-Glutamic Acid support the acidic environment pepsin needs to work, the spark that sets off every later stage of digestion.
- Easier on dairy: Lactase breaks down lactose, easing the bloating and discomfort many people feel after milk products.
- Easier digestion of vegetables and fiber: Humans do not make cellulase, so this enzyme helps break plant cell walls and release the nutrients locked inside.
- A friendlier gut environment: Probiotics and a blend of parsley, ginger, fennel, peppermint and rosemary are classic additions for tummy comfort, and well-digested food leaves less fuel for unwanted microbes.
How Ultra-Zyme Works in the Body
Digestion is not a single event but a relay, where each stage triggers the next. It starts in the stomach: hydrochloric acid converts pepsinogen into active pepsin to begin breaking down protein, sterilizes food, and helps you absorb vitamin B12, iron and zinc. When that acidic food moves into the small intestine, its acidity is the very signal that tells the pancreas to release enzymes and the gallbladder to contract and release bile. In other words, low stomach acid does not just weaken protein digestion. It weakens everything downstream.
That is the often-missed root cause: many cases of heartburn, burping and heaviness come from too little acid, not too much. Food sits in the stomach longer, ferments, and pushes up against the upper valve. Stomach acid tends to decline with age, with chronic stress (cortisol and the fight-or-flight state shut digestion down), with low zinc, and with long-term use of antacids and acid-blocking medications.
The second link is the liver and gallbladder. The liver makes bile and the gallbladder stores it. When bile is thick or scarce, fat is not emulsified, leading to fullness under the right ribs, nausea after greasy meals and oily stools. Thick bile is closely tied to insulin resistance, fatty liver and diets high in sugar and refined oils, and people without a gallbladder no longer have a bile reservoir at all. This is where Ox Bile provides ready-made bile salts, while Pancreatin supplies the lipase to finish the job.
The third link is the gut. Undigested food becomes food for unwanted bacteria and yeast, driving gas, bloating and an unbalanced microbiome. That is why this formula pairs enzymes with probiotics, lactase and cellulase, to reduce how much undigested food reaches the colon. You get more from it when you address the drains at the same time: eat slowly and chew well, since digestion starts in the mouth; avoid gulping large amounts of water with meals, which dilutes stomach acid; cut back on sugar and refined starches that feed fermentation and burden the liver; avoid eating while stressed; and include bitter greens and fermented foods that stimulate digestive juices.
What Makes This Formula Stand Out
Ultra-Zyme's strength is that it does not rely on a single enzyme type. It covers all three stages of digestion in two tablets. Its Pancreatin is 4x (quadruple strength) at 325 mg per two tablets, supplying 32,500 USP units of amylase, 32,500 USP units of protease and 2,600 USP units of lipase. These units come from the Pancreatin itself, not separate additions. Fat digestion is backed by 120 mg of Ox Bile, an ingredient missing from many plant-only enzyme blends. Protein digestion is supported from several angles: Pepsin NF (1:10,000), Bromelain (1:10) and Papain. L-Glutamic Acid and Betaine HCl support stomach acidity, while Lactase and Cellulase handle dairy and fiber. Rounding it out are three probiotic strains (Lactobacillus acidophilus, Lactobacillus bulgaricus and Bifidobacterium bifidum) and a Whole Food Blend of parsley leaf, rosemary leaf, ginger root, fennel seed and peppermint leaf. The tablets are finished with pharmaceutical glaze, and the once-daily dosing means one bottle lasts 45 days.
Who Is This Product For?
- People who deal with bloating, heaviness and burping after meals, especially protein-rich ones.
- Anyone who struggles with fatty foods, has a sluggish gallbladder, or has had their gallbladder removed.
- Older adults, or anyone under chronic stress that dampens digestive secretions.
- People who have used antacids long term and feel their digestion is not what it used to be.
- Those who have trouble digesting milk and dairy products.
- Anyone eating a diet rich in protein and healthy fats who wants to support their digestion and nutrient absorption.
How to Use
Per the label, take two tablets once daily as a dietary supplement. Since digestive enzymes act on the food in your digestive tract, the best time is with your main meal of the day, or at the start of it, ideally the meal richest in protein and fat. Swallow the tablets with a little water and avoid drinking large amounts during the meal. To get the most out of it, eat slowly and chew thoroughly in a calm setting away from rushing and screens, and cut back on sugar and frequent snacking that never gives your digestive system a break.
Product Details
- Pancreatin 4x (quadruple strength): 325 mg per 2 tablets, supplying Amylase 32,500 USP units, Protease (trypsin & chymotrypsin) 32,500 USP units and Lipase 2,600 USP units.
- L-Glutamic Acid: 200 mg per 2 tablets.
- Ox Bile: 120 mg per 2 tablets.
- Bromelain (1:10) (from pineapple stem): 100 mg per 2 tablets.
- Pepsin NF (1:10,000): 65 mg per 2 tablets.
- Papain (from papaya): 65 mg per 2 tablets.
- Cellulase: 20 mg per 2 tablets.
- Probiotics (L. acidophilus, L. bulgaricus, B. bifidum): 17 mg per 2 tablets.
- Whole Food Blend (Parsley Leaf, Rosemary Leaf, Ginger Root, Fennel Seed, Peppermint Leaf): 21 mg per 2 tablets.
- Betaine HCl: 5 mg per 2 tablets.
- Lactase: 5 mg per 2 tablets.
- Form: Coated tablets.
- Count: 90 tablets, a 45-day supply at two tablets daily.
- Allergen note: Pepsin contains trace wheat, so this product is not gluten-free. Pancreatin, Pepsin and Ox Bile are animal-derived.
- Brand: NaturesPlus.
Frequently Asked Questions
Should digestive enzymes be taken before or after eating?
The best time is with a meal or right at the start of it, because enzymes need food present to work on. Taking them on an empty stomach misses the digestive purpose, and taking them long after eating reduces their usefulness.
Do digestive enzymes help with bloating and gas?
Bloating after meals is often the result of food that was not fully digested and ended up fermenting in the gut. Supporting the breakdown of protein, fat, starch and milk sugar reduces how much undigested food reaches the colon, which is why enzymes are a go-to for meal-related bloating, alongside a look at diet and sugar intake.
Why does this formula include Ox Bile?
Fat cannot be digested by enzymes alone. It first needs bile to emulsify it into tiny droplets that lipase can work on. When the gallbladder is sluggish or removed, or bile thickens with fatty liver and insulin resistance, ready-made bile salts offer direct support for fat digestion and absorption of fat-soluble vitamins.
Is it suitable for people who avoid gluten?
No. The label states that the pepsin contains trace wheat, so the product is not gluten-free. It is also not suitable for vegetarians, as it contains animal-derived ingredients.
Caution
Consult your doctor if pregnant, nursing, managing a stomach ulcer or taking long-term medication.
